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Improvements in the DQE of direct electron detectors combined with their ability to operate in movie mode, have created unique opportunities for the development of computational strategies in single-particle cryo-EM. By harnessing the time-resolved information contained in movie frames, we developed methods to account for local variations in defocus and beam-induced drift, and implemented a data-driven dose compensation scheme that allowed us to overcome fundamental resolution barriers inherent to imaging biological samples using high-energy electrons.
This presentation is part of Minisymposium “MS51 - Algorithms for Single Particle Reconstruction in Cryo-Electron Microscopy (cryo-EM). (3 parts)”
organized by: Roy Lederman (Yale University) , Joakim Andén (Flatiron Institute) .